Glutathione Metabolism and Psychological Functions

5-oxoproline activity amino acid amino acid uptake autoxidation bimolecular Biochem Biol biological systems Biophys Ca++ catalytic Chem compounds concentration cysteine derived detection DMPO DMPO-OH electron enzyme ESR spectrum Figure Flohé formed free radical formation glutathione peroxidase glyoxalase GSH depletion GSH levels GSH synthesis GSSG hepatic hepatocytes hydrogen hydroperoxide hydroxyl radical formation hydroxyl radicals hyperfine splitting hyperfine splitting constants inhibition isolated hepatocytes J. R. Viña kinetic Ladenstein lipid peroxidation Meister membrane metabolism mixed disulfides MNP spin adducts monosaccharides NADPH nitrone nitroso nitroxide observed oxygen peptides phenazine phenyl primaquine protein radical spin adduct reactive free radical redox reduced reductase selenium selenocysteine selenocysteine residue selenolate spectra spin adducts spin trapping spin trapping reaction spin trapping technique substrate superoxide and hydroxyl superoxide radicals superoxide spin adduct synthetase thiol thiyl radicals tion tissues transpeptidase trapping of superoxide W. A. Günzler xenobiotic y-glutamyl cycle y-glutamyl transpeptidase